Melphalan, Antimelanoma Immunity, and Inflammation—Response

Melphalan, Antimelanoma Immunity, and Inflammation--Response.

cells for Mel-ILP responsiveness, in a subset of melanoma patients (2). However, in our opinion, it is tough to conclude from the results Martner and colleagues present that melphalan alone can induce immunogenic cell death (ICD), and additional analyses are required to validate this clinically (1, 3). For instance, T-cell effector responses intratumorally are known to differ from those in peri...

Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.

Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients. Because checkpoint blockade acts by "removing the brakes" on effector T cells, the efficacy of checkpoint blockade may be constrained by the limited pool of melanoma-reactive T cells in the periphery. In the thymus, aut...

Activation Immunity through Localized TLR7/8 Effective Innate and Adaptive Antimelanoma

Antimelanoma and Antityrosinase from Alpinia galangal Constituents

Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the prol...

Antibodies testing, Immunity and immunity passport in Covid-19

The global outbreak of coronavirus disease-2019 (COVID-19) has affected most countries in the world. Our knowledge of diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is evolving, and it is important to have a clear understanding of the nature of the tests and the interpretation of their findings. In this paper, the purpose is to interpret the results of two typ...